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(Note: The CDC no longer recommends aspiration for vaccines, but many clinics still teach it for IM injections of other substances.) Inject slowly over 5-10 seconds

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However, it is important to note that the analysis of the present review focused primarily on the folate-dependent pathway, which constitutes a limitation because it excludes other nutrients involved in epigenetic regulation, such as choline, serine and vitamins B12 and B6, all of which participate in SAM availability and overall methylation capacity (175,176)