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Genes Variations or mutations of certain hydroxylation genes - particularly CYP1B1 and CYP3A4 - are known for the increased production of potentially harmful estrogens such as 4OHE1 and 16aOHE1
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Inheritance of the Peg11/RTL1 KO allele from father causes late fetal lethality due to late fetal growth retardation, whereas maternal transmission leads to overexpression of Peg11/Rtl1 and neonatal lethality (196, 197)