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Additionally, the functional imbalances that are caused by Tylenol are also independently associated with autism: Oxidative Stress 6,7 and Systemic Inflammation 8,9 Disruption of the GI Microbiome 10,11,12 MTHFR genetic polymorphism 13,14,15,16,17 The Central Problem: How Tylenol Depletes Your Body's Master Antioxidant (Glutathione) When you take acetaminophen, a small percentage of it is detoxified via cytochrome P450 oxidation to become NAPQI (N-acetyl-p-benzoquinone imine)—a highly reactive, toxic metabolite

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However, there are no clinical studies examining this combination