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Fe 3+ is reduced to Fe 2+ in the intestinal lumen by iron-reducing enzymes, including duodenal cytochrome b reductase (Dcytb), and transported to the enterocytes via the divalent metal 1 transporter (DMT1)

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In the United States, the FDA and the Code of Federal Regulations (CFR) play central roles in setting the standards for AE reporting, whereas the European Medicines Agency (EMA) oversees these activities in Europe