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Crystals of ShHTL1 were grown by mixing 0.45 μL of purified ShHTL1 protein solution (15.0 mg mL −1 ) with 0.45 μL of reservoir solution containing 100 mM Tris (pH 8.5), 150 mM MgCl 2 , and 23% (w/v) PEG6000 and allowing the drop to equilibrate at 5 °C