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The reviewers themselves frame that contrast not as a conclusion but as a call to action, repeatedly noting the “critical need for well-designed human trials.” For anyone surveying the field, holding both halves at once — the breadth of the preclinical signal and the thinness of the human evidence — is what separates reading the science from reading the marketing

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The stronger the trial design, meaning randomized, placebo-controlled, and conducted on a larger number of participants, the more confidently you can apply the results to real people