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Known risks and side effects: Increased appetite, commonly reported and documented at a substantially higher rate on MK-677 than placebo (67% versus 36% of participants) in the Nass et al

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265,266 When GLP-1 binds to its receptors in the hypothalamus, it activates specific neurons, including those that promote satiety (POMC/CART neurons) and inhibits those that induce hunger (NPY/AgRP neurons), thereby enhancing the feeling of fullness and reducing food intake