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It functions as a potent vasodilator, modulates smooth muscle activity in the gastrointestinal tract, and participates in neurotransmission in the central and peripheral nervous systems (Lelievre et al., 2008)

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Nanoparticles with in-situ Gel Formulation The combination of an ISG and the nanoparticle system alleviates the loss of the administered formulation by mucociliary clearance and facilitates nanoparticle uptake by the nasal membrane (Table 5)

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