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In basic environments, it undergoes hydrolytic degradation and alpha, beta-unsaturated beta-diketone moiety cleavage ( Reports have shown that 90% of curcumin degradation under alkaline and neutral conditions occurred within 15–30 min, while in acidic incubations, degradation was substantially slower, with less than 20% of total curcumin degraded within 60 min ( 9.2 Autooxidation of curcumin Curcumin is also susceptible to autooxidation, which occurs through radical chain reactions and spontaneously occurs in aqueous solutions (187)

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Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications