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(1988) in The Roots of Modern Biochemistry: Fritz Lipman's Struggle and Its Consequences (Kleinkauf H., von Dohren H., Jaenicke L

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These approaches often rely on the conservation of the metal–ligand residues in the primary structure in a group of closely related enzymes using pattern-matching, and recent computational methods have been used to distinguish adventitious from physiologically relevant sites worthy of detailed study 65 as well as distinguish catalytic from noncatalytic structural sites 66 have recently been reported