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Ipamorelin acts as an agonist at the ghrelin receptor (GHSR-1a) in the pituitary gland, stimulating the release of growth hormone through activation of specific signaling pathways (PMID: 9849822)

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Li, known as a notable bioactive compound in hematological malignancies, it has been used in the clinical treatment of leukemia in China since 1970s, and it was approved by FDA for the treatment of chronic myeloid leukemia (CML) with resistant to tyrosine kinase inhibitors in 2012