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The H + is supplied through the enzyme NADPH-cytochrome P450 oxidoreductase and its cofactor NADPH

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Parental ZR-75-1 cells were cultured in Phenol-red free medium containing 10% Dextran-coated charcoal-stripped FBS (DCC) with increasing concentration of Tamoxifen, starting from 0.5 μM initially, and finally up to 5 μM in a period of about 6 months