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In other studies, increased plasma TMAO was associated with increased risk of cardiovascular death, poor peripheral artery disease (PAD) prognosis (Roncal et al., 2019), heart failure (HF) via the gut–TMAO–HF axis (Zhang et al., 2021) and functionally relevant coronary artery disease ( Dietary salt and trimethylamine N-oxide in salt-sensitive hypertension Hypertension can also be driven by high dietary salt (sodium) intake, hence the term salt-sensitive hypertension (Mishra et al., 2018)

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doi: 10.3389/fimmu.2022.815168 61 DerouicheS