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Pickart and Margolina (2018) documented over 4,000 genes influenced by GHK-Cu, many involved in tissue remodeling well beyond the dermis (Int J Mol Sci, 19(7):1987)
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Although the mechanisms that underlie resistance to improvement require further investigation, it is possible that the IGF-1 LR3 unresponsiveness in established FGR is due to other factors characteristic of FGR fetuses including hypoxemia, prolonged glucose and amino acid deprivation, or elevated cortisol and catecholamines, all factors that can suppress insulin secretion (5) and therefore the positive growth effects of increased circulating IGF-1 concentrations