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In hMDMs, DAT is highly responsive to inflammatory stimuli, as LPS treatment reduces DAT-mediated uptake and increases DAT-mediated dopamine efflux by promoting an efflux-favoring conformation in these cells

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This mechanism is physiologically important as hepatocytes supply GSH found in the plasma, which is used as a source of cysteine for GSH synthesis in other cells (Anderson et al., 1980)

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