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Efficacy and safety of subcutaneous semaglutide in adults with overweight or obese: A subgroup meta-analysis of randomized controlled trials

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In 2010, it was discovered that human UGTs mediate glucuronidation reaction by using a serine hydrolase-like mechanism, which involves two key amino acids histidine and aspartic acid (so-called “catalytic dyad” or “acid base pair”) (Radominska-Pandya et al., 2010)