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145 Under oxidative stress, Cys34 thiol shifts to a sulfenic acid (HSA-SOH), which can be irreversibly oxidized to the sulfinic (HSA-SO2H) and sulfonic (HSA-SO3H) acids or, through the reactions with glutathione, can be returned to the HSA-SH reduced form

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However, this susceptibility of patients with T2DM to adverse outcomes associated with SARS-CoV-2 infection is due to impaired immune system function, and possible up regulation of enzymes that mediate viral invasion