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In published research, Melanotan-2 is studied for its effects on melanocortin receptor signalling, melanocyte tyrosinase activity and the eumelanin/pheomelanin synthesis ratio (via MC1R), hypothalamic regulation of food intake and energy balance (via MC4R), central pathways relevant to sexual behaviour, and macrophage anti-inflammatory signalling (via MC1R/MC3R)

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