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Recent clinical data suggests they are well-tolerated , but they should only be used under medical supervision

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While this prominent role for the kidneys in GSH turnover / GSH conjugate metabolism certainly aligns with the tissue distribution of GGT activity, analysis of total renal extraction of plasma GSH during a single pass of the blood through the renal circulation was observed to be much more than could be accounted for by the process of glomerular filtration [16–21]