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While many compounds can force the growth of new blood vessels (angiogenesis), they often do so in a disorganized way that can lead to leaky vessels or unwanted tissue growth

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Along this conduit, the brain interacts with the gut through neural components (CNS and ANS), endocrine system (hypothalamic-pituitary-adrenal axis), immune components (cytokines and metabolic) and gastrointestinal components (microbiota, intestinal barrier and intestinal immune response) (Oświęcimska et al., 2017)