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10.1556/2054.2019.013 10.1556/2054.2019.013 [DOI] [Google Scholar] 81.Moloudizargari M, Mikaili P, Aghajanshakeri S et al (2013) Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids

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The field has evolved from the 2-minute half-life of native GLP-1 to engineered analogs that persist for a week — a 5,000-fold improvement achieved through fatty acid conjugation, D-amino acid substitution, cyclization, and depot formulations