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Among these RTAs, the strategy that has recently attracted the greatest interest, particularly in the context of cancer, is targeting the enzymes that regulate the ubiquinol (CoQ 10 H 2 , reduced) pool to sensitize cancer cells to ferroptosis

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Interestingly, it was found that Parkin ubiquitinates PHB2 and stimulates the interaction among PHB2 and LC3 to enhance mitophagy, where PHB2 serves as both the receptor for autophagosome recruitment and the basis for ubiquitin-mediated autophagosome recruitment [84]

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