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What the trials found about high-dose oral tablets Kuzminski and colleagues, publishing in Blood (1998), randomized 38 patients with newly diagnosed B12 deficiency to either 2,000 mcg oral cyanocobalamin daily or the standard 1,000 mcg intramuscular schedule

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Freezing can cause freeze-concentration, where ice formation pushes the acid and peptide into shrinking pockets of liquid, concentrating the acid and damaging the peptide structure during the freeze-thaw process