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Acetaminophen overdose: N-acetylcysteine, administered either intravenously or orally, to restore glutathione levels Activated charcoal to absorb excess drug If acute liver failure occurs, intensive supportive therapy or liver transplantation may be required NSAID toxicity: Gastroprotective agents to prevent or treat gastric ulcers (eg, proton pump inhibitors [eg, omeprazole]) What are Emerging Therapies for Acetaminophen and NSAID Toxicity