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Keywords: Clostridium butyricum , enterotoxigenic Escherichia coli K88, oxidative damage, p62-Keap1-Nrf2 signaling pathway, cecal microbiota, mice Introduction Oxidative stress occurs when the production rate of free radicals in the body [mainly reactive oxygen species (ROS) and reactive nitrogen species (RNS)] exceeds the elimination rate of the body’s antioxidant system, resulting in an imbalance in oxidant and antioxidant effects (1)