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After reviewing literature and conducting a two-round Delphi survey with 42 experts, a consensus emerged that emphasizes prioritizing clinical symptoms in diagnosis, with serum B12 as a screening marker supported by methylmalonic acid or homocysteine levels for additional confirmation

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Acknowledgements We thank the laboratory technicians in our animal unit at Novo Nordisk (Måløv, Denmark) for daily caretaking and for overseeing our experiments