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Understanding Oxidative Stress and Liver Damage The liver is constantly exposed to harmful substances that generate free radicals—unstable molecules that can damage liver cells

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GSH transport into mitochondria appears to be mediated in part by the dicarboxylate carrier (DIC, Slc25a10) and the oxoglutarate carrier (OGC, Slc25a11) (Lash, 2006), whereas transport into the nucleus probably occurs by passive diffusion through the nuclear pores