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Within the TME, tumor-derived factors and local hypoxia drive adipocyte dedifferentiation, lipolysis, loss of adipocyte markers, ECM remodeling traits, and heightened secretion of cytokines/adipokines

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Arabidopsis seedlings with impaired GSNOR1 function exhibited increased levels of protein-SNO and deficiencies in development, immunity, and thermotolerance 59,70,86