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Intranasal administration enables direct access to the brain via the olfactory and trigeminal neural pathways, effectively bypassing the blood-brain barrier

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Estimation of NAPQI, different sulfate and glucuronide metabolites in hepatic tissue and serum, and a survival study of APAP have not been evaluated in this study which could add more confirmation for APAP toxicity and PA role in APAP-induced hepatotoxicity