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55–57 Moreover, Chinese herbal formulas like Tong-Xie-Yao-Fang and Tong-Xie-Ning , composed of Atractylodis macrocephalae , Paeoniae alba , Citrus reticulata , and Saposhnikoviae , have shown significant efficacy in randomized controlled trials (RCTs) for treating diarrhea-predominant IBS, reducing pain frequency and improving stool consistency

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When the gut barrier is compromised, toxins and inflammatory compounds can enter the bloodstream and trigger inflammation that manifests in the skin, leading to breakouts, irritation, and other issues

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