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In an experimental study carried out by Chen Y et al., 2018, it was determined that, in Sprague Dawley rats fed a High fat diet (HFD) during 12 weeks, the authors demonstrated that APS1 significantly reduced body weight and also reduced the accumulation of hepatic lipids regulating the expression of SIRT-1/PGC-1α/SREBP-1, as well as the increase in hepatic antioxidant activity on modulating the expression of activity of NRF-2 and HO-1 [51]