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Key Research Findings HGF/c-Met Receptor Activation — Facilitates dimerization of the hepatocyte growth factor receptor, activating downstream PI3K/Akt and MAPK/ERK signaling cascades involved in neuronal survival Synaptogenic Activity — Preclinical research demonstrated promotion of new dendritic spine formation and synaptic connections in hippocampal neurons at picomolar concentrations Cognitive Research — Animal studies showed enhanced performance in spatial learning and memory tasks (Morris water maze, radial arm maze) in models of cognitive impairment Blood-Brain Barrier Penetration — Unlike parent angiotensin IV peptides, Dihexa was engineered for oral bioavailability and CNS penetration Neurotrophic Factor Modulation — Research suggests amplification of endogenous HGF signaling rather than direct receptor activation, potentiating existing neurotrophic pathways Specifications Reported Side Effects in Research Limited safety data
