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The latter can occur naturally, such as the opioid peptide dermorphin isolated from frog skin, peptidoglycans of some microorganisms, or venom peptides—conotoxins containing D -tryptophan ( D -Trp), D -leucine ( D -Leu), etc

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At the time of the switch, a subset of patients expressed concerns about the long-term impact that it would have on their condition management, and in an online survey many stated that they were dissatisfied with the level of care received