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Studied for its effect on NF-kB and MAP kinase, the signaling routes that switch inflammatory genes on Reported active at nanomolar concentrations, which points to a targeted signaling effect rather than a blunt chemical one Enters cells through PepT1, a transporter for small peptides found on immune cells and lining cells, which is why gut models dominate the literature Acne inflammation runs through the same NF-kB pathway, and that overlap is the honest basis for the interest

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NAD-based inhibitors with anticancer potential [PMID: 24269162] Laboratory literature summary: NAD-based inhibitors with anticancer potential