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The standard escalation protocol Your healthcare provider will typically increase your dose by 2.5 mg every 4 weeks, following this progression: Week 1–4: 2.5 mg Week 5–8: 5 mg Week 9–12: 7.5 mg Week 13–16: 10 mg Week 17–20: 12.5 mg Week 21+: 15 mg (maximum dose) Four weeks is the minimum time at each dose, but it is not a fixed deadline

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The study identified increased proportions of pro-inflammatory and mesenchymal fibroblast subpopulations, elevated p16 protein and SA-β-galactosidase-positive cells, and enhanced SASP gene expression in keloid tissue