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Furthermore, a notable increase in the level was seen after a two-month administration of glutathione therapy (142 ± 5) in comparison to the control group (127 ± 3) (Figure 2B)

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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig