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Acetaminophen has a very high oral bioavailability of 60–88% ( C max ) is 12.3 μg/ml, area under the curve over 6 h (AUC 0–6 ) is 29.4 μg/h/ml, and AUC extrapolated to infinity (AUC 0–∞ ) is 44.4 μg/h/ml

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The need for these mimetics arises from a fundamental pharmacological challenge: BDNF itself is a terrible drug candidate

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