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To achieve an ≈50% inhibition of eicosanoids, mice were given 50 mg/kg curcumin per day orally [71], while, in the RCT, a concentration of 500 mg/day was used in patients with AR [142]

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Likewise, deep phenotyping and machine learning methodologies combined in the nomothetic precision psychiatry approach have significantly enhanced our molecular understanding of the different MDD phenotypes and features and their relationships with NIMETOX pathways [8, 229, 238]