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While this might suggest limited importance of the oxPPP in T reg cells, knockout of Pgd specifically in T reg cells (driven by Foxp3- Cre) causes severe T reg dysfunction in mice, which die because of autoimmunity between days 20 and 30 of life 119

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This format is particularly suited to high-throughput research protocols and laboratories conducting extended experimental series requiring consistent dual-component dosing across multiple trial phases