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The historical pivot that defined MT-II’s modern research identity occurred during the compound’s first human pilot phase I clinical study conducted at the University of Arizona, when male volunteers undergoing subcutaneous MT-II dose escalation for tanning research reported spontaneous penile erections — with 8 of 10 men developing clinical erections in a subsequent placebo-controlled crossover study, with a mean tip rigidity duration of 38 minutes versus 3 minutes on placebo