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Dysregulation of urate transporters in the proximal convoluted tubule constitutes the principal determinant of net urinary excretion ( 2.2.3 Regulatory role of intestinal excretion Quantitative contribution: Using C14 tracer studies, Sorensen (1965) demonstrated that a significant portion of total body uric acid turnover (∼1/3) is excreted via the intestine (extrarenal elimination pathway) compared to ∼2/3 excreted renally ( 2.2.4 Mechanisms of renal and intestinal urate reabsorption and excretion Renal and intestinal handling of urate relies on specific transporters to maintain systemic urate levels

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The iPLEDGE program, which governs isotretinoin prescribing in the United States, requires two forms of contraception for people who can become pregnant