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GPX1 is ubiquitous in cytoplasm and mitochondria, formerly known as cytoplasmic GPX (CGPX), is the first discovered member of the GPx family, almost all cell mitochondria and cytoplasm can be detected, it is also one of the most widely expressed and highest content of selenoproteins in the human body (Alehagen et al., 2021), its main role is to catalyze glutathione (GSH) to reduce toxic peroxides in the body, including hydrogen peroxide, cholesterol peroxide and long-chain fatty acid peroxide (Alehagen et al., 2021

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Future Directions: Cagrilintide in 2026 and Beyond The landscape of cagrilintide research and clinical application continues to evolve rapidly as we progress through 2026