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Lysosomes, as well as late endosomes and autophagosomes, have a thin layer of lysosomal glycocalyx on their inner surfaces (77) that protects the membranes from being digested by the hydrolytic enzymes they contain (78)

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Additionally, drugs like metformin and simvastatin, which can penetrate the blood-brain barrier and alter metabolic pathways, have shown great feasibility in the treatment of gliomas