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The Clinical Approach: Research-Based Supportive Care Because of the DPC model’s flexibility, Jose’s clinician had time to: Review published case reports on ciguatera treatment approaches Study the toxin’s mechanism of action at the cellular level Research supportive therapies that address oxidative stress Design a monitoring protocol to track response The clinical rationale for IV glutathione : Given that ciguatoxin generates significant oxidative stress in affected tissues, the team considered high-dose antioxidant therapy as a supportive intervention