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In rodent models, prolonged or binge alcohol exposure activates nuclear factor kappa-B (NF-KB) pathways and increases lipid peroxides, nitrite levels, NADPH oxidase (NOX), cytochrome c oxidase II, and reactive O 2 - and O 2 - derived oxidants in brain [74-76]

Glutathione and various synergy vitamins work together to build an antioxidant network that delivers glutathione more efficiently for oxidation