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335 Itaconate restrains NF-κB activation through dual mechanisms: the derivative 4-OI alkylates Keap1 to activate the NRF2-HO-1/NQO1 pathway, thereby suppressing NF-κB activity and the production of TNF-α, IL-1β, and IL-6 in SLE PBMCs and THP-1 macrophages 336

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It produces the most consistent results, allows precise dose titration, and matches the route used in nearly all preclinical research