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In the context of continuing to take SMG, it is important to understand the risk of more serious long-term adverse effects, such as pancreatitis, intestinal obstruction, and gastroparesis [185], or even the effect of loss of lean mass [179]

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(4) Given the variability in weight loss with SMG, it will be important to find prognostic predictors that identify those who do not respond to SMG (loss of less than 5% of weight) and those who are super-responders (loss of more than 20% of weight) [183]