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For example, elesclomol enhanced the cytotoxic effects of paclitaxel specifically in melanoma cells with high OXPHOS [65]

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Although strategies such as iron chelators (e.g., deferoxamine), antioxidants (e.g., N-acetylcysteine), and GPX4 activation demonstrate neuroprotective potential in animal and cellular models, their safety, tolerability, blood-brain barrier permeability, and ability to modulate disease progression in humans have not been systematically validated