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GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis

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Source: Gojkovic et al., 2021 How BPC-157 Protects Against Alcohol Damage Four mechanisms explain why BPC-157 works across so many organ systems simultaneously