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Ultimately, activation of wnt in fibroids leads to increased concentrations of β-catenin in the nucleus where it binds to T-cell factor (TCF) and lymphocyte enhancement factor (LEF) transcription factors, resulting in the expression of target genes involved in cell differentiation, survival, and neoplasia [86]

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Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5 alpha-reductase inhibitor